FISH probes provide a practical method for detecting gene aberrations, including gene amplification, deletion, chromosome/gene copy number change, chromosome translocation, gene expression at the RNA level, and bacterial/viral detection.

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DNA microarrays (or DNA chips) have been the most commonly used technique during the last two decades to globally monitor the cellular abundances of transcript species. A DNA microarray is a collection of microscopic DNA spots attached to a solid surface. Each DNA spot contains many thousands of copies of a specific DNA sequence, known as probes. These usually correspond to a short section of a gene generally at the 3′ end. Each microarray contains one or a few probe sets for each interrogated gene. These are used to hybridize a cDNA sample (the target) under high-stringency conditions. Probe–target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine the relative abundance of transcripts in the target sam

Chromosome analysis or karyotyping is a test that evaluates the size, shape, and number of chromosomes. Extra or missing chromosomes, or abnormal locations of chromosome pieces, can cause problems with growth, development, and physical functions. Chromosome analysis is usually a helpful test to determine the genetic contribution to a constellation of medical and/or developmental problems. In addition, stem cells in culture can accumulate changes including chromosomal abnormalities. Alterations in the genome can lead to changes in gene expression and cellular functions, increasing the risk of stem cell tumorigenesis. Therefore, it is crucial to monitor a culture for any chromosomal abnormalities, particularly in stem cells intended for therapeutic use.

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Numerous technologies have been developed for 3D models including scaffold-based (such as ECM-based hydrogels) cell cultures and scaffold-free cell cultures (such as spheroids). 3D models have been widely employed in various research areas. In cancer research, 3D tumor models, recapitulating the tumor microenvironment, have been increasingly utilized in studying tumorigenesis and anti-cancer drug discovery as excellent models. A variety of cell sources can be used to generate 3D models, including cell lines, primary cells, and genetically modified cells. However, establishment of a proper 3D models fitting to special applications can be complex and resource-demanding, and requires in-depth knowledge.

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With our over 10 years' experiences of working with tumor cell lines, Creative Bioarray provides cell proliferation assay service for our customers. We provide optional assay methods based on the cell type and protocol, and on the customer’s preference of proliferation measurement.

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To better preserve the genomic integrity and tumor heterogeneity observed in patients, patient-derived xenograft (PDX) models were generated using freshly resected patient tumors immediately transplanted into immunocompromised murine hosts without an intermediate in vitro culture step. Creative Bioarray focuses on anti-tumor drug research and development services to help customers assess the efficacy of compounds and study the associated pathological mechanisms.

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Creative Bioarray offers a broad range of well-characterized xenograft, patient-derived xenograft (PDX), syngeneic tumor models as well as genetically engineered mouse models (GEMMs). Combining these models with appropriate biomarkers, including flow cytometry and imaging, our portfolio allows our partners to select the most appropriate study design and screening method to identify promising compounds and optimize lead candidates.

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Creative Bioarray provides integrated discovery solutions for small molecules. Led by senior scientific leadership with global discovery experience and backed by multidisciplinary chemists and biologists, we have a proven track record of transitioning discovery programs into clinical practice. Balancing productivity with innovation, and working closely with customers, we quickly and efficiently generate preclinical candidates for successful IND filing.

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Creative Bioarray is an industry leader in bioanalysis services for the cosmetics industry. More than half of our scientific staff have Doctor/Master degrees and boast 10+ years of experience in cell-based assays. Our team brings the highly specialized assay expertise, veteran insights, and innovative technology needed to accelerate the success of your cosmetic trials.

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Creative Bioarray offers cell line stability testing services to companies and research institutes in pharmaceuticals, tissue engineering, antibody or vaccine production. Our range of advanced technologies allows testing to be performed throughout the life cycle of the producing cell line and to assess the genetic stability of the Master Cell Bank (MCB), Working Cell Bank (WCB), and End-of-Production Cells (EOPC).

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Cells are structural and functional unit of our body which control and maintain the function of all unicellular and multicellular organisms. The process of cell proliferation and differentiation plays a key role from the time of embryogenesis to development of whole organism from single- or double- cell embryo and continues its critical role in maintenance of adult tissue homoeostasis by recycling the old cells with new cells. Besides, abnormal cell proliferation is also associated with human diseases like cancer. In sum, cell proliferation assays are very important in scrutinizing the rate of cell proliferation in both in vitro and in vivo conditions.

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Creative Bioarray has extensive experiences in developing highly functional 3D cell culture models that exhibit more physiological relevance.

The conventional two-dimension (2D) culture systems in which cells grow on flat glass or polystyrene substrates have been routinely applied in life science researches and drug discovery for the past decades. However, 2D cell culture has been continuously challenged for its incompetence to mimic natural structural organization in a living organism. Cells cultured in a two-dimension environment exhibit compromised properties such as morphology, proliferation, differentiation and response to drugs.

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Creative Bioarray offers a comprehensive set of general toxicology studies ranging from non-GLP dose-ranging studies to GLP-compliant repeat-dose toxicology studies. We can perform tests that meet ICH standard or design tailored studies for the evaluation of toxicological effects. Our general toxicology studies range from single-dose to repeated-dose assessment in a variety of animal species using multiple routes of administration including oral, intravenous, dermal topical, ocular and intravitreal injections. Our team of preclinical experts always provides high quality, timely reports with complete regulatory compliance to support your research programs and the regulations you submit.

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Creative Bioarray has deep expertise in the profiling, identification and structural characterization of metabolites in vitro and in vivo. We use advanced technology and software for accurate, reliable metabolite identification and structural characterization. In addition, synthetic chemistry services are available to undertake synthesis of metabolites, reference standards, and internal standards to aid in method development and metabolite identification.

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Evaluating the potential side effects of human pharmaceuticals on the immune system should be incorporated into standard drug development process. Toxicity to the immune system includes inhibition or enhancement of the immune response. Inhibiting the immune response can result in a decrease in host resistance to infectious agents or tumor cells, while enhanced immune response can exacerbate autoimmune diseases or allergies. Currently, the assessment of immunotoxic effects depends on different animal models. With a few exceptions, the immune system of humans and experimental animals are very similar. Most drugs that inhibit the immune system in humans produce similar results in rodents, and the mechanisms for immunosuppressive action are similar.

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