Protein phosphorylation is a reversible post-translational modification (PTM) that acts as a molecular switch for many cellular events. The activation and deactivation of signaling pathways through phosphorylation by kinases or dephosphorylation by phosphatases are under delicate control.

Approximately one-third of proteins in the human proteome are presumed to be phosphorylated during their life cycle, accounting for an estimated 100,000 different phosphorylation sites. Protein phosphorylation often leads to structural changes which then affect protein functions by modulating protein folding, substrate affinity, stability, localization and activity. https://www.cd-biosciences...