A family of stimulus-responsive biomaterials for regulated drug administration is called elastin-like polypeptides, or ELPs. Short repeating peptide motifs with VPGXP, where X is a guest residue that can be any amino acid other than proline, make up the structure of ELPs. ELPs, a stimulus-responsive biomaterial, aggregate form a micron-sized coacervate at a temperature over the reverse transition temperature (Tt) after being fully dissolved in an aqueous solution below Tt. This phase shift is reversible and can be finished quickly; that is, the ELP coacervate will re-dissolve when its temperature drops below Tt. More intriguingly, the Tt of ELPs can be modified by varying the ELPs' length and guest residues.
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