Creative Biogene has established fully-matured RNAi system, ranges from design, siRNA synthesis/shRNA construction, transfection, expression evaluation to functional testing. On this basis, we offer cell-based RNAi service to verify the silencing effects of siRNA transient transfection and/or shRNA incorporation and stable expression. Creative Biogene has the ability to accurately evaluate the silencing activities of shRNA and siRNA, and assist you to screen shRNA/siRNA with high knockdown efficiency.

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Creative Biogene, as a leader in cell engineering, provides reliable, affordable, and fast knock-in cell line generation service, which includes gRNA/donor DNA construction, PCR sequencing, and engineered cell line generation. We have experience working with a wide variety of cell backgrounds ranging from easy-to-transfect cell lines (like HEK2993, HCT116 or HeLa) to hard-to-transfect cell lines (like iPSCs, fibroblasts). Creative Biogene produces knock-in cell lines and performs quality control testing in one step to help ensure that the cell line meets your requirements.

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Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats)/Cas9 systems is a newly developed yet the most popular method for genome editing. It has been widely used in current biology, functional genome screening, cell-based human hereditary disease modeling, epigenomic studies and visualization of cellular processes.

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Creative Biogene is a microbiotech company offering high-quality gene expression services in Bacillus for our esteemed clients around the world across both academic institutions and biotech/pharmaceutical industries. With our strong technical force, we specialize in providing more cost-effective gene expression services to accelerate the global research in microbial enzymes and recombinant proteins.

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Pseudomonas aeruginosa is a Gram-negative, rod-shaped bacterium known for its adaptability and versatility in various environments. Most Pseudomonas species are facultative anaerobes and use an inorganic compound such as nitrate as alternate terminal electron receptor. P. aeruginosa is capable of arginine fermentation and pyruvate fermentation. The organism produces the fluorescent siderophores pyoverdin and pyochelin, which function to scavenge iron. Redox-active phenazines such as pyocyanin, the pigment that gives P. aeruginosa its characteristic blue color, play an important role in electron transport especially under microaerophilic conditions, increase the bioavailability of iron, and enhance virulence through oxidative stress.

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Creative Biogene is a leading biotechnology company offering the best Salmonella genome editing services. With years of experience and expertise in microbial genome editing, our talented scientists will work closely with you to provide any help in Salmonella genome editing services.

Salmonella is the foodborne pathogen with the biggest public health and economic impact globally. It's one of the major causes of diarrhea all around the world, responsible for an estimated one million deaths and 100 million human infections annually. Genomic information decoded from a multitude of different Salmonella strains and new dramatic insights into pathogenic processes emphasize the fact that Salmonella research is currently at a very exciting juncture.

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